Menthol
Monoterpene
Menthol is a chiral monoterpene used orally, topically, and by inhalation. Route, stereochemistry, formulation, and rapid glucuronidation make those exposures non-interchangeable.
Pharmacokinetic model
A route-level PK model for menthol is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Monoterpene
- Suggested cadence
- once daily
Research behind this entry
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Randomised trial: Peppermint oil (menthol) pharmacokinetics in children and effects on gut motility in children with functional abdominal pain
Children received weight-based enteric-coated peppermint oil, and menthol glucuronide was used as the exposure marker. The results are formulation- and metabolite-specific and cannot validate a generic free-menthol…
1 published study referenced in the app, each with a plain-language summary.