Magnolia Bark
Magnolia officinalis bark preparations used in traditional medicine and sold for calming or other claims. Chemistry and toxicology are better characterized than clinical efficacy, and commercial extracts are not pharmacokinetically interchangeable.
Pharmacokinetic model
A route-level PK model for magnolia bark is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Herb
- Suggested cadence
- once daily
Research behind this entry
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Pharmacokinetic and Metabolic Profiling of Key Active Components of Dietary Supplement Magnolia officinalis Extract for Prevention against Oral Carcinoma
Mouse study measured three defined Magnolia constituents and found very low oral bioavailability with extensive first-pass conjugation. It supports constituent-specific modeling but cannot validate a human whole-extract…
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Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents
Review catalogued Magnolia chemistry, experimental activities, and safety findings. Much of the evidence was preclinical, with preparation variability and limited clinical confirmation.
2 published studies referenced in the app, each with a plain-language summary.