Lycopene

Carotenoid

Lycopene is a red carotenoid found chiefly in tomatoes and sold in several food-derived and purified formulations. Supplement trials demonstrate absorption, but outcome evidence varies by formulation and population and does not justify treating food, oleoresin, and purified products as one PK profile.

Pharmacokinetic model

A route-level PK model for lycopene is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category: Carotenoid
Suggested cadence: once daily

Research behind this entry

Tomato and lycopene and multiple health outcomes: Umbrella review Li N, Wu X, Zhuang W, Xia L, Chen Y, Wu C, Rao Z, Du L, Zhao R, Yi M, Wan Q, Zhou Y · Food Chemistry, 2021 DOI
This umbrella review synthesized meta-analyses across many outcomes and found that certainty and effect direction varied. It combines tomato foods and lycopene interventions, so it cannot define a purified-lycopene dose…
A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress Devaraj S, Mathur S, Basu A, Aung HH, Vasu VT, Meyers S, Jialal I · Journal of the American College of Nutrition, 2008 DOI
Seventy-seven adults were randomized to 0, 6.5, 15, or 30 mg/day of purified lycopene for eight weeks after a restricted-diet run-in. Plasma lycopene rose at all active doses, while most oxidative-stress biomarkers did…
The effects of lycopene supplement on the spermatogram and seminal oxidative stress in infertile men: A randomized, double-blind, placebo-controlled clinical trial. Nouri M, Amani R, Nasr-Esfahani M, Tarrahi MJ · Phytotherapy research : PTR, 2019 DOI
This citation reports a human clinical study involving Lycopene. It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.

3 published studies referenced in the app, each with a plain-language summary.