Limonene (D-Limonene)
Citrus Monoterpene
Limonene is a chiral monoterpene; D- or R-limonene predominates in citrus peel. Essential oils contain many other terpenes. Human capsule PK exists, but claims for reflux, anxiety, or cancer are not established by that bioequivalence study.
Pharmacokinetic model
A route-level PK model for limonene (d-limonene) is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Citrus Monoterpene
- Suggested cadence
- once daily
Research behind this entry
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Bioequivalence evaluation of two D-limonene capsule formulations in healthy Chinese volunteers
Twenty-four healthy men completed a randomized three-period crossover comparison of two 0.3-mL D-limonene capsule products and a no-dose period. The products met bioequivalence criteria; this PK result does not…
1 published study referenced in the app, each with a plain-language summary.