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Leafy greens (vitamin K)

Foodoral · inferred

Kale/spinach/collards deliver vitamin K1 (phylloquinone). Directly antagonises warfarin via VKORC1/GGCX cycle. Sudden increase OR decrease destabilises INR.

Projected serum levels — 1 cup (≈ 1 mg), as needed (shown daily)

Leafy greens (vitamin K)
Leafy greens (vitamin K) modeled serum levels, 1 cup (≈ 1 mg) as needed (shown daily) over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 7 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 7

Maintenance schedule: 1 cup (≈ 1 mg) as needed (shown daily) (oral).

Modeled steady state after ~7 days: peak ≈ 0 mg, trough ≈ 0 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Food
Route modeled
Oral
Model confidence
inferred
Common dose
1 cup (≈ 1 mg)
Suggested maximum
3 cup/day
Reference dose range
1–3 cup (single dose)
Suggested cadence
as needed (shown daily)

Documented interactions

  • danger
    Warfarin (Coumadin) + Leafy greens (vitamin K) Depletion

    High vitamin K intake from leafy greens (spinach, kale, broccoli, Brussels sprouts) directly antagonizes warfarin's VKORC1 inhibition. Vitamin K is the essential cofactor for clotting factor…

  • moderate
    Vitamin K2 (MK-7) + Leafy greens (vitamin K) Stacked effects

    Leafy greens (vitamin K) and Vitamin K2 (MK-7) both push the gamma glutamyl carboxylase and vkorc1 in the same direction.

Serum checks 2 modeled interaction pairings for leafy greens (vitamin k) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.