L-Tyrosine
Proteinogenic large neutral amino acid synthesized from phenylalanine and obtained from dietary protein. It is a precursor for catecholamines, thyroid hormones, and melanin. Supplement trials suggest that acute cognitive effects are context-dependent and most plausible during severe short-term stress or high cognitive demand; evidence does not support a general treatment effect or reliable enhancement under ordinary conditions.
Projected serum levels — 2k mg, once daily
Maintenance schedule: 2k mg once daily (oral).
Modeled steady state after ~1 days: peak ≈ 1.7k mg, trough ≈ 227 mg body load. Population-based estimate over 15 days for a 2k mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.
Key facts
- Category
- Amino Acid
- Route modeled
- Oral
- Model confidence
- inferred
- Half-life
- 7.4 h
- Common dose
- 2k mg
- Suggested maximum
- 10.5k mg/day
- Reference dose range
- 500–10.5k mg (single dose)
- Suggested cadence
- once daily
- Validated against
- 7k mg oral — Cmax 15.4 mg/L at 2 h
Research behind this entry
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Elevation of plasma tyrosine after a single oral dose of L-tyrosine
In 12 fasting healthy participants, oral 100 or 150 mg/kg L-tyrosine increased plasma tyrosine and its ratio to competing large neutral amino acids, with peaks at about 2 hours and elevation persisting for 2-8 hours.…
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Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands
Review finding variable results across tyrosine studies. Benefits were most consistent during short-term stressful or cognitively demanding conditions likely to strain catecholamine synthesis; evidence for clinical…
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Tyrosine supplementation for phenylketonuria
Cochrane review found three usable trials totaling 56 participants with phenylketonuria. Supplementation increased blood tyrosine but did not significantly improve the other measured clinical outcomes, so routine use…
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Evaluation of the Safety and Tolerability of L-Tyrosine Supplementation in Healthy Adult Men: A Randomized Crossover Trial.
This citation reports a human clinical study involving L-Tyrosine. It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.
4 published studies referenced in the app, each with a plain-language summary.