L-Serine
Amino Acid Supplement
L-serine is a proteinogenic amino acid and metabolic precursor. It must be distinguished from D-serine and from racemic serine; high-dose research in rare metabolic neuropathy does not imply benefit or safety for routine use.
Pharmacokinetic model
A route-level PK model for l-serine is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Amino Acid Supplement
- Suggested cadence
- once daily
Research behind this entry
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Randomized trial of L-serine in patients with hereditary sensory and autonomic neuropathy type 1
Eighteen adults with genetically defined HSAN1 were randomized to 400 mg/kg/day L-serine or placebo for one year before an open-label extension. The rare-disease mechanism and very high dose do not establish benefit,…
1 published study referenced in the app, each with a plain-language summary.