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Kisspeptin-10

Peptidesubcutaneous · inferred

C-terminal decapeptide fragment of kisspeptin, a potent GnRH stimulator. Half-life ~4 minutes in humans. Stimulates robust LH and FSH release through hypothalamic GnRH neuron activation via the KISS1R/GPR54 receptor. Used in research to probe HPG axis function and fertility. Much shorter acting than kisspeptin-54 (half-life ~28 min).

Projected serum levels — 1 nmol/kg (≈ 0.091 mg), once daily

Kisspeptin-10
Kisspeptin-10 modeled serum levels, 1 nmol/kg (≈ 0.091 mg) once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1
Kisspeptin-10 modeled serum levels with a loading dose of 1.4 nmol/kg, then 1 nmol/kg (≈ 0.091 mg) once daily The first dose is larger so levels approach steady state faster. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule

Maintenance schedule: 1 nmol/kg (≈ 0.091 mg) once daily (subcutaneous).

Loading schedule: 1.4 nmol/kg on day 1, then 1 nmol/kg (≈ 0.091 mg) once daily — reaching therapeutic levels sooner.

Modeled steady state after ~1 days: peak ≈ 0.000 mg, trough ≈ 0.000 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Peptide
Route modeled
Subcutaneous
Model confidence
inferred
Half-life
4 min
Common dose
1 nmol/kg (≈ 0.091 mg)
Suggested maximum
10 nmol/kg/day
Reference dose range
0.50–10 nmol/kg (single dose)
Suggested cadence
once daily

Research behind this entry

  1. LC-MS/MS quantification of kisspeptin-10 and characterization of its decomposition product and pharmacokinetics in rats Liu Z et al. · Journal of Chromatography B, 2013 DOI

    Developed sensitive LC-MS/MS assay for kisspeptin-10 quantification showing rapid degradation with half-lives of 6.8, 2.9, and 1.7 min at 4C, 25C, and 37C respectively in rat plasma.

  2. Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency in Men Chan YM et al. · Journal of Clinical Endocrinology & Metabolism, 2011 DOI

    Demonstrated IV kisspeptin-10 produced rapid, dose-dependent LH secretion in healthy men with increased LH pulse frequency, confirming its role as a potent GnRH secretagogue.

  3. The Effects of Kisspeptin-10 on Reproductive Hormone Release Show Sexual Dimorphism in Humans Dhillo WS et al. · Journal of Clinical Endocrinology & Metabolism, 2005 DOI

    First study demonstrating kisspeptin-10 stimulates gonadotropin release in humans with sex-dependent differences, establishing kisspeptin as a key reproductive hormone regulator in humans.

3 published studies referenced in the app, each with a plain-language summary.