Home › Compound Library › Infliximab (Remicade)

Infliximab (Remicade)

Biologicprescriptioniv · inferred

Chimeric (mouse-human) IgG1 monoclonal antibody targeting TNF-alpha. IV infusion 5 mg/kg at weeks 0, 2, 6, then every 8 weeks (dose/interval adjusted by indication and TDM). Approved for Crohn's disease, ulcerative colitis, RA, psoriatic arthritis, AS, plaque psoriasis. Biphasic PK with terminal half-life ~8-10 days. 100% IV bioavailability. Higher immunogenicity than fully human antibodies, anti-drug antibodies accelerate clearance and lower trough levels. Therapeutic drug monitoring (target trough 5-10 mcg/mL depending on IBD target) increasingly standard.

Projected serum levels — 400 mg, custom (shown daily)

Infliximab (Remicade)
Infliximab (Remicade) modeled serum levels, 400 mg custom (shown daily) over 72 days Population-based pharmacokinetic estimate. Steady state reached after approximately 18 days. 0 1.3k 2.5k 3.8k 5k Day 0 Day 18 Day 36 Day 54 Day 72 Time on a regular schedule ≈ steady state · day 18
Infliximab (Remicade) modeled serum levels with a loading dose of 1.2k mg, then 400 mg custom (shown daily) The first dose is larger so levels approach steady state faster. 0 1.3k 2.5k 3.8k 5k Day 0 Day 18 Day 36 Day 54 Day 72 Time on a regular schedule

Maintenance schedule: 400 mg custom (shown daily) (iv).

Loading schedule: 1.2k mg on day 1, then 400 mg custom (shown daily) — reaching therapeutic levels sooner.

Modeled steady state after ~18 days: peak ≈ 4.0k mg, trough ≈ 3.6k mg body load. Population-based estimate over 72 days for a 400 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Biologic
Route modeled
IV
Model confidence
inferred
Half-life
9.4 days
Common dose
400 mg
Suggested maximum
800 mg/day
Reference dose range
200–800 mg (single dose)
Suggested cadence
custom (shown daily)
Validated against
350 mg iv — Cmax 118 mg/L at 2 h

Documented interactions

  • watch
    Etanercept (Enbrel) + Infliximab (Remicade) Stacked effects

    Etanercept (Enbrel) and Infliximab (Remicade) both push the tnf alpha in the same direction.

Serum checks 1 modeled interaction pairings for infliximab (remicade) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Clinical pharmacokinetics and use of infliximab Klotz U et al. · Clinical Pharmacokinetics, 2007 DOI

    Comprehensive PK review: biphasic disposition, terminal t1/2 ~8-10 days, IV administration, impact of ADA on clearance and clinical outcomes.

  2. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial Hanauer SB et al. · Lancet, 2002 DOI

    Pivotal ACCENT I trial establishing infliximab maintenance dosing (5 mg/kg q8w) for Crohn's disease, the template for modern IBD therapy.

2 published studies referenced in the app, each with a plain-language summary.