Idebenone
Synthetic Benzoquinoneprescription
Idebenone is a short-chain synthetic benzoquinone related to coenzyme Q10 but not interchangeable with it. Its clinical use has been studied mainly in specific mitochondrial diseases; those results do not support general nootropic or antioxidant claims.
Pharmacokinetic model
A route-level PK model for idebenone is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Synthetic Benzoquinone
- Suggested cadence
- once daily
Research behind this entry
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A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy
Eighty-five patients with genetically defined LHON received 900 mg/day idebenone or placebo for 24 weeks. The prespecified primary endpoint was not significant overall; post-hoc and subgroup findings are…
1 published study referenced in the app, each with a plain-language summary.