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Ibuprofen Extended Release (Advil 12 Hour)

Analgesicoral · predicted

Sustained-release 600 mg ibuprofen matrix tablet providing up to 12 hours of relief. Swallow the tablet whole; do not crush, chew, split, or dissolve it.

Projected serum levels — 600 mg, once daily

Ibuprofen Extended Release (Advil 12 Hour)
Ibuprofen Extended Release (Advil 12 Hour) modeled serum levels, 600 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 125 250 375 500 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 600 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 381 mg, trough ≈ 44.3 mg body load. Population-based estimate over 15 days for a 600 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Analgesic
Route modeled
Oral
Model confidence
predicted
Half-life
2.5 h
Common dose
600 mg
Suggested maximum
1.2k mg/day
Reference dose range
600–1.2k mg (single dose)
Suggested cadence
once daily

Research behind this entry

  1. Single dose oral ibuprofen for acute postoperative pain in adults Derry C et al. · Cochrane Database of Systematic Reviews, 2009 DOI

    Cochrane review found ibuprofen 400 mg provided effective analgesia in over 70% of patients with moderate to severe postoperative pain, with NNT of 2.5.

  2. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials Coxib and traditional NSAID Trialists Collaboration · Lancet, 2013 DOI

    Major meta-analysis of 280,000+ participants found high-dose ibuprofen increased coronary events similarly to COX-2 inhibitors, while naproxen did not increase vascular risk.

  3. Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review Pierce CA et al. · Annals of Pharmacotherapy, 2010 DOI

    Meta-analysis found ibuprofen provided superior pain relief and fever reduction compared to acetaminophen in both children and adults, with comparable safety profiles.

3 published studies referenced in the app, each with a plain-language summary.