Indole-3-Carbinol (I3C)
Dietary Indole
I3C is formed from glucobrassicin in cruciferous vegetables. In the acidic stomach it forms multiple condensation products, so I3C and DIM are not interchangeable identities.
Pharmacokinetic model
A route-level PK model for indole-3-carbinol (i3c) is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Dietary Indole
- Suggested cadence
- once daily
Research behind this entry
-
Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmethane
Women received 400 to 1200 mg oral I3C. Parent I3C was not detected; DIM was the only quantified derivative, showed high interindividual variability, and exposure plateaued above 1000 mg.
1 published study referenced in the app, each with a plain-language summary.