Hypericin
Naphthodianthrone
Hypericin is a photoreactive constituent of St. John's wort. Pure hypericin and standardized botanical extracts have different co-constituents and kinetics.
Pharmacokinetic model
A route-level PK model for hypericin is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Naphthodianthrone
- Suggested cadence
- once daily
Research behind this entry
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Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John's wort plant, in patients with chronic hepatitis C virus infection
Nineteen patients received 0.05 or 0.10 mg/kg/day pure hypericin for eight weeks. No meaningful antiviral effect occurred, and phototoxic reactions affected most participants at the higher dose.
1 published study referenced in the app, each with a plain-language summary.