Hyperforin
Hyperforin is a phloroglucinol derivative found in Hypericum perforatum and a major driver of St. John's-wort drug interactions through PXR-mediated induction. Isolated hyperforin and variable botanical extracts must not inherit one another's doses or kinetics.
Pharmacokinetic model
A route-level PK model for hyperforin is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- St. John's Wort Constituent
- Suggested cadence
- once daily
Research behind this entry
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Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers
Two phase-I studies in 18 healthy men measured hyperforin after a specific 900 mg Hypericum extract tablet, reporting about 122 ng/mL Cmax, 4.5-hour Tmax, and 17.5-hour half-life after one dose. These values are tied to…
1 published study referenced in the app, each with a plain-language summary.