Hyaluronic Acid
A size-heterogeneous glycosaminoglycan used in oral supplements and multiple local medical or cosmetic formulations. Evidence and exposure are formulation- and route-specific; one recent oral skin trial cannot be generalized to all hyaluronic acid products.
Pharmacokinetic model
A route-level PK model for hyaluronic acid is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Supplement
- Suggested cadence
- once daily
Research behind this entry
-
Oral sodium hyaluronate improves skin hydration, barrier function and signs of aging: a randomized, double-blind, placebo-controlled trial in 150 healthy adults
Twelve-week trial randomized 150 healthy Caucasian adults to 60 mg, 120 mg, or placebo using one 1.8 MDa sodium-hyaluronate solution. Several skin measures favored treatment, especially 120 mg, but most authors were…
-
Hyaluronic Acid—A Powerful Biomolecule with Wide-Ranging Applications—A Comprehensive Review
Broad review describes hyaluronan biology, molecular-weight-dependent behavior, degradation, and diverse pharmaceutical or biomaterial uses. It supports treating route and formulation as distinct rather than assigning…
2 published studies referenced in the app, each with a plain-language summary.