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Humanin

Peptidesubcutaneous · inferred

Mitochondrial-derived peptide (MDP) encoded by the 16S rRNA region of mtDNA. 24-amino-acid peptide with cytoprotective and metabolic regulatory functions. Half-life ~30 min in mice (>4 hours in rats); kinetics influenced by IGFBP-3 binding. Circulating levels decline with age. The S14G analog (HNG) has enhanced potency and is used in most studies.

Projected serum levels — 1 mg, once daily

Humanin
Humanin modeled serum levels, 1 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 0.25 0.50 0.75 1 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 1 mg once daily (subcutaneous).

Modeled steady state after ~1 days: peak ≈ 0.40 mg, trough ≈ 0.000 mg body load. Population-based estimate over 15 days for a 1 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Peptide
Route modeled
Subcutaneous
Model confidence
inferred
Half-life
29 min
Common dose
1 mg
Suggested maximum
4 mg/day
Reference dose range
0.50–4 mg (single dose)
Suggested cadence
once daily

Research behind this entry

  1. Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents Muzumdar RH et al. · Endocrinology, 2009 DOI

    First PK study of humanin analogs showing species-dependent half-lives (30 min in mice, >4 h in rats) and that IGFBP-3 binding capacity determines circulating kinetics and distribution.

  2. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan Cobb LJ et al. · Aging, 2020 DOI

    Demonstrated humanin levels correlate with longevity, decline with age, and exogenous humanin treatment improved healthspan metrics including cognitive function and metabolic health in mice.

  3. Humanin and Its Pathophysiological Roles in Aging: A Systematic Review Cai H et al. · Frontiers in Aging Neuroscience, 2023 DOI

    Systematic review covering humanin roles in Alzheimer disease neuroprotection, metabolic regulation, cardiovascular protection, and its decline during normal aging.

  4. Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents. Chin YP, Keni J, Wan J, Mehta H, Anene F, Jia Y, Lue YH, Swerdloff R, Cobb LJ, Wang C, Cohen P · Endocrinology, 2013 DOI

    This citation reports an animal study involving Humanin. It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.

4 published studies referenced in the app, each with a plain-language summary.