Honokiol

Magnolia Lignan

Honokiol is a biphenolic lignan found in Magnolia bark. Isolated honokiol, magnolia extracts, and intravenous liposomal honokiol have different composition and disposition.

Pharmacokinetic model

A route-level PK model for honokiol is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category: Magnolia Lignan
Suggested cadence: once daily

Research behind this entry

A validated ultra-HPLC-MS/MS method for determination of honokiol in human plasma and its application to a clinical pharmacokinetic study Zhuang Q, Pan R, Liu X, Xu W, Wang H, Zhang X, Lai X, Wang H, Zhang L, Jiang J · Bioanalysis, 2019 DOI
Investigators validated a plasma assay and applied it to first-in-human pharmacokinetics of honokiol liposome injection in Chinese patients with advanced non-small-cell lung cancer. It confirms measurable human exposure…

1 published study referenced in the app, each with a plain-language summary.