Guarana

Herb

Paullinia cupana seed products used mainly as stimulants. Effects often overlap with caffeine, while extract composition and caffeine standardization vary enough that generic guarana cannot inherit caffeine's PK curve.

Pharmacokinetic model

A route-level PK model for guarana is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category: Herb
Suggested cadence: once daily

Research behind this entry

Effects of the consumption of guarana on human health: A narrative review Torres EAFS, Pinaffi-Langley ACDC, Figueira MS, Cordeiro KS, Negrão LD, Soares MJ, da Silva CP, Alfino MCZ, Sampaio GR, de Camargo AC · Comprehensive Reviews in Food Science and Food Safety, 2022 DOI
Narrative review surveyed guarana composition and human or experimental outcomes. It did not establish effects independent of caffeine across indications and emphasized heterogeneous products and evidence.
Cognitive effects of guarana supplementation with maximal intensity cycling Gurney T, Bradley N, Izquierdo D, Ronca F · British Journal of Nutrition, 2023 DOI
Controlled exercise study examined one guarana formulation around maximal cycling and selected cognitive outcomes. The narrow setting and formulation prevent generalization to daily cognitive enhancement.

2 published studies referenced in the app, each with a plain-language summary.