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Guanfacine (Tenex)

Antihypertensive / Alpha-2 Agonistprescriptionoral · inferred

Selective central alpha-2A adrenergic agonist used for hypertension (immediate release, Tenex) and ADHD (extended release, Intuniv). Reduces sympathetic outflow and strengthens prefrontal cortical network regulation. Half-life ~17 hours; ~50% excreted renally unchanged, the remainder metabolized mainly by CYP3A4. Abrupt discontinuation can cause rebound hypertension; taper when stopping.

Projected serum levels — 1 mg, once daily

Guanfacine (Tenex)
Guanfacine (Tenex) modeled serum levels, 1 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 2 days. 0 0.50 1 1.5 2 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 2
Guanfacine (Tenex) modeled serum levels with a loading dose of 1.6 mg, then 1 mg once daily The first dose is larger so levels approach steady state faster. 0 0.50 1 1.5 2 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule

Maintenance schedule: 1 mg once daily (oral).

Loading schedule: 1.6 mg on day 1, then 1 mg once daily — reaching therapeutic levels sooner.

Modeled steady state after ~2 days: peak ≈ 1.1 mg, trough ≈ 0.49 mg body load. Population-based estimate over 15 days for a 1 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Antihypertensive / Alpha-2 Agonist
Route modeled
Oral
Model confidence
inferred
Half-life
17 h
Common dose
1 mg
Suggested maximum
4 mg/day
Reference dose range
0.50–4 mg (single dose)
Suggested cadence
once daily
Validated against
1 mg oral — Cmax 0.002 mg/L at 2.6 h