Grape Seed Extract
Grape-seed extract is a polyphenol-rich botanical mixture whose composition depends on cultivar, extraction, and standardization. Small trials and pooled analyses report selected vascular or inflammatory outcomes, but results cannot be transferred automatically between products.
Pharmacokinetic model
A route-level PK model for grape seed extract is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Botanical Extract
- Suggested cadence
- once daily
Research behind this entry
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The effect of grape seed extract supplementation on oxidative stress and inflammation: A systematic review and meta-analysis of controlled trials
This meta-analysis pooled controlled trials across products and populations. Some biomarkers changed, but substantial differences in extracts and protocols limit product-level inference and provide no…
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Effects of Grape Seed Extract Supplementation on Endothelial Function and Endurance Performance in Basketball Players
Twelve elite athletes received grape-seed extract or placebo for 14 days. Selected cycling and flow-mediated-dilation measures favored the extract, but the very small, short study cannot establish general performance…
2 published studies referenced in the app, each with a plain-language summary.