Gonadorelin
Synthetic gonadotropin-releasing hormone used diagnostically and in specialized pulsatile fertility therapy. It is distinct from long-acting GnRH agonists and from ganirelix, a GnRH antagonist.
Pharmacokinetic model
A route-level PK model for gonadorelin is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Peptide Medicine
- Suggested cadence
- once daily
Research behind this entry
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Modulatory effects of gonadorelin on GABA-induced depolarization and GABA-activated current in rat spinal ganglion neurons
Rat-neuron experiment examined gonadorelin modulation of GABA responses. It does not establish a neurologic indication or clinical benefit in humans.
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Pharmacokinetics of gonadotropin-releasing hormone: comparison of subcutaneous and intravenous routes
Human study showed lower, delayed, and prolonged GnRH exposure after SC delivery compared with IV administration, including about one-third lower steady-state levels during continuous SC infusion.
2 published studies referenced in the app, each with a plain-language summary.