Glutathione

Endogenous Antioxidant

Endogenous tripeptide central to cellular redox control and xenobiotic metabolism. Supplement products differ substantially by chemical form and route, while blood measurements do not directly represent intracellular tissue pools. A biochemical role does not by itself establish benefit from routine supplementation in people without a defined indication.

Pharmacokinetic model

A route-level PK model for glutathione is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category
Endogenous Antioxidant
Suggested cadence
once daily

Research behind this entry

  1. An Update on Glutathione's Biosynthesis, Metabolism, Functions, and Medicinal Purposes Gasmi A, Nasreen A, Lenchyk L, Lysiuk R, Peana M, Shapovalova N, Piscopo S, Komisarenko M, Shanaida M, Smetanina K, Antonyak H, Fira L, Lykhatskyi P, Fira D, Bjorklund G · Current Medicinal Chemistry, 2024 DOI

    Broad narrative review covers glutathione synthesis, redox metabolism, cellular functions, measurement, and proposed medical uses. It supports glutathione's biological importance but does not establish a universal…

  2. Glutathione metabolism and its implications for health Wu G, Fang YZ, Yang S, Lupton JR, Turner ND · Journal of Nutrition, 2004 DOI

    Review describes glutathione synthesis, turnover, nutrient precursors, antioxidant functions, and disease associations. Mechanistic and deficiency evidence should not be interpreted as proof that exogenous glutathione…

  3. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Richie JP, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE · European journal of nutrition, 2015 DOI

    This citation reports a human clinical study involving Glutathione. It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.

3 published studies referenced in the app, each with a plain-language summary.