Glucosamine Sulfate
Amino sugar naturally found in cartilage. Supports joint structure and may slow osteoarthritis progression. Synovial fluid concentrations persist longer than plasma levels.
Projected serum levels — 1.5k mg, once daily
Maintenance schedule: 1.5k mg once daily (oral).
Loading schedule: 2.2k mg on day 1, then 1.5k mg once daily — reaching therapeutic levels sooner.
Modeled steady state after ~2 days: peak ≈ 498 mg, trough ≈ 188 mg body load. Population-based estimate over 15 days for a 1.5k mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.
Key facts
- Category
- Joint Support
- Route modeled
- Oral
- Model confidence
- inferred
- Half-life
- 15 h
- Common dose
- 1.5k mg
- Suggested maximum
- 3k mg/day
- Reference dose range
- 750–3k mg (single dose)
- Suggested cadence
- once daily
- Validated against
- 1.5k mg oral — Cmax 1.6 mg/L at 2.5 h
Research behind this entry
-
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis (GAIT)
Large NIH-funded RCT of 1,583 patients found glucosamine alone was not superior to placebo overall, but the combination with chondroitin showed significant benefit in moderate-to-severe knee pain.
1 published study referenced in the app, each with a plain-language summary.