Gamma-Linolenic Acid (GLA)
Omega-6 Fatty Acid
GLA is an 18:3 omega-6 fatty acid found in oils such as evening primrose and borage. It is distinct from alpha-linolenic acid despite the shared abbreviation and enters regulated esterified lipid pools after ingestion.
Pharmacokinetic model
A route-level PK model for gamma-linolenic acid (gla) is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Omega-6 Fatty Acid
- Suggested cadence
- once daily
Research behind this entry
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Gamma-Linolenic Acid versus Alpha-Lipoic Acid for Treating Painful Diabetic Neuropathy in Adults: A 12-Week, Double-Placebo, Randomized, Noninferiority Trial
One hundred adults with painful diabetic neuropathy received 320 mg/day GLA or 600 mg/day alpha-lipoic acid for 12 weeks. Seventy-three completed treatment; noninferiority depended on the selected pain endpoint and the…
1 published study referenced in the app, each with a plain-language summary.