Ghrelin
Endogenous 28-amino-acid peptide hormone; the octanoylated form activates the growth-hormone secretagogue receptor. It is distinct from des-acyl ghrelin and from synthetic receptor agonists such as GHRP-6 or ibutamoren.
Pharmacokinetic model
A route-level PK model for ghrelin is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Peptide Hormone
- Suggested cadence
- once daily
Research behind this entry
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Molecular Mechanisms and Health Benefits of Ghrelin: A Narrative Review
Narrative review describes ghrelin biology across appetite, neuroendocrine, cardiovascular, and metabolic systems. It is a mechanism overview, not evidence that exogenous ghrelin is a generally useful or safe consumer…
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The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects
Controlled infusions in healthy adults showed dose-proportional acyl and total ghrelin exposure, lower clearance for des-acyl ghrelin, and conversion from acyl to des-acyl ghrelin. Those distinct analytes cannot be…
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Ghrelin decreases sensitivity to negative feedback and increases prediction-error related caudate activity in humans, a randomized controlled trial.
This citation reports a human clinical study involving Ghrelin. It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.
3 published studies referenced in the app, each with a plain-language summary.