Gamma-Tocopherol
Vitamin E Isoform
Gamma-tocopherol is a tocopherol isoform distinct from alpha-tocopherol and from gamma-tocotrienol. Human handling favors alpha-tocopherol retention, while gamma-tocopherol is cleared more rapidly to CEHC metabolites.
Pharmacokinetic model
A route-level PK model for gamma-tocopherol is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Vitamin E Isoform
- Suggested cadence
- once daily
Research behind this entry
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Studies in humans using deuterium-labeled alpha- and gamma-tocopherols demonstrate faster plasma gamma-tocopherol disappearance and greater gamma-metabolite production
Fourteen adults received about 50 mg each of deuterium-labeled alpha- and gamma-tocopheryl acetates. Labeled gamma-tocopherol disappeared more than three times faster, with about 13-hour half-life and greater CEHC…
1 published study referenced in the app, each with a plain-language summary.