Follistatin 344 (FS344)

Experimental Protein

FS344 refers to a follistatin precursor isoform sequence and is also used ambiguously on research-product labels. AAV1-FS344 gene therapy and an injected recombinant follistatin protein are different modalities; no marketed vendor vial should inherit gene-therapy evidence.

Pharmacokinetic model

A route-level PK model for follistatin 344 (fs344) is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category: Experimental Protein
Suggested cadence: once daily

Research behind this entry

Follistatin gene delivery enhances muscle growth and strength in nonhuman primates Kota J, Handy CR, Haidet AM, Montgomery CL, Eagle A, Rodino-Klapac LR, Tucker D, Shilling CJ, Therlfall WR, Walker CM, Weisbrode SE, Janssen PM, Clark KR, Sahenk Z, Mendell JR, Kaspar BK · Science Translational Medicine, 2009 DOI
Cynomolgus macaque muscles received AAV1 vectors encoding FS344 and showed local muscle growth and strength changes. This was nonhuman gene delivery, not dosing of follistatin-344 protein, and cannot validate retail…

1 published study referenced in the app, each with a plain-language summary.