Folinic Acid (Leucovorin)
Folinic acid is 5-formyltetrahydrofolate and is used medically as leucovorin, including methotrexate rescue and chemotherapy modulation. It is distinct from folic acid and L-methylfolate. High-dose or oncology use belongs under clinician-directed treatment.
Pharmacokinetic model
A route-level PK model for folinic acid (leucovorin) is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Reduced Folate
- Suggested cadence
- once daily
Research behind this entry
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Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial
Forty-eight children with autism and language impairment were randomized to high-dose folinic acid or placebo for 12 weeks. Verbal-communication scores improved more with folinic acid, especially in a biomarker-defined…
1 published study referenced in the app, each with a plain-language summary.