L-Ergothioneine
Dietary Thione
L-ergothioneine is a diet-derived sulfur-containing amino-acid derivative transported by OCTN1/SLC22A4 and concentrated in blood cells and tissues. Human uptake is demonstrated, while broad antioxidant, cognition, and longevity outcomes remain unproven.
Pharmacokinetic model
A route-level PK model for l-ergothioneine is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Dietary Thione
- Suggested cadence
- once daily
Research behind this entry
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Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation
Healthy volunteers received pure oral ergothioneine while plasma, whole blood, urine, metabolites, and biomarkers were measured. Ergothioneine was absorbed and retained with less than 4% urinary recovery, but most…
1 published study referenced in the app, each with a plain-language summary.