Epithalon (Epitalon)
Synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the pineal gland peptide epithalamin. Activates telomerase in human somatic cells, elongating telomeres. Studied for anti-aging effects. Half-life estimated at <1 hour due to its small tetrapeptide structure. Typically administered as 5-10 mg SC daily for 10-20 day cycles.
Projected serum levels — 5 mg, once daily
Maintenance schedule: 5 mg once daily (subcutaneous).
Modeled steady state after ~1 days: peak ≈ 2.0 mg, trough ≈ 0.000 mg body load. Population-based estimate over 15 days for a 5 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.
Key facts
- Category
- Peptide
- Route modeled
- Subcutaneous
- Model confidence
- inferred
- Half-life
- 29 min
- Common dose
- 5 mg
- Suggested maximum
- 10 mg/day
- Reference dose range
- 2.5–10 mg (single dose)
- Suggested cadence
- once daily
Research behind this entry
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Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
Demonstrated that Epithalon induced telomerase expression, enzymatic activity, and telomere elongation in human fetal fibroblast cultures that were previously telomerase-negative.
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Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties
Comprehensive review of Epitalon covering telomerase activation, melatonin regulation, antioxidant effects, and evidence from over two decades of research into anti-aging applications.
2 published studies referenced in the app, each with a plain-language summary.