Ecdysterone

Supplement

Phytoecdysteroid marketed for anabolic and sports-performance effects. One small human supplementation study reported body-composition and performance signals, but product characterization and replication are insufficient for firm clinical conclusions.

Pharmacokinetic model

A route-level PK model for ecdysterone is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category: Supplement
Suggested cadence: once daily

Research behind this entry

Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans Isenmann E, Ambrosio G, Joseph JF, Mazzarino M, de la Torre X, Zimmer P, Kazlauskas R, Goebel C, Botrè F, Diel P, Parr MK · Archives of Toxicology, 2019 DOI
Ten-week resistance-training study reported greater gains in some muscle and performance measures with ecdysterone. The modest sample, supplement characterization, and limited replication prevent broad efficacy claims.
Estrogen receptor beta is involved in skeletal muscle hypertrophy induced by the phytoecdysteroid ecdysterone Parr MK, Zhao P, Haupt O, Ngueu ST, Hengevoss J, Fritzemeier KH, Piechotta M, Schlörer N, Muhn P, Zheng WY, Xie MY, Diel P · Molecular Nutrition and Food Research, 2014 DOI
Cell and animal experiments implicated estrogen receptor beta in ecdysterone-associated muscle effects. Mechanistic preclinical findings do not establish anabolic efficacy or safety in humans.

2 published studies referenced in the app, each with a plain-language summary.