Coluracetam
Coluracetam (MKC-231) is an experimental compound studied mainly in preclinical high-affinity choline-uptake models. No approved indication, established human dosing standard, or demonstrated cognitive benefit supports consumer use.
Pharmacokinetic model
A route-level PK model for coluracetam is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Investigational Nootropic
- Suggested cadence
- once daily
Research behind this entry
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Ketamine and other potential glutamate antidepressants
Review focuses on ketamine and other glutamatergic antidepressant candidates and only mentions coluracetam among compounds of interest. It provides no direct coluracetam efficacy, safety, or pharmacokinetic evidence…
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MKC-231, a choline uptake enhancer: (3) Mode of action of MKC-231 in the enhancement of high-affinity choline uptake
Preclinical synaptosome and binding experiments suggested that MKC-231 increases membrane availability of the CHT1 choline transporter. This mechanistic work does not demonstrate human cognitive or antidepressant…
2 published studies referenced in the app, each with a plain-language summary.