Citrulline Malate
Exercise supplement combining L-citrulline with malate, commonly sold in nominal 1:1 or 2:1 ratios. Evidence is mixed and product composition must not be treated as equivalent to a stated dose of pure L-citrulline.
Pharmacokinetic model
A route-level PK model for citrulline malate is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Amino Acid Combination
- Suggested cadence
- once daily
Research behind this entry
-
A critical review of citrulline malate supplementation and exercise performance
Critical review found methodological and product-composition problems across the exercise literature, including uncertainty about the added value of malate and actual citrulline content.
-
Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis
Meta-analysis reported a small average increase in repetitions after acute citrulline-malate use, with heterogeneity and limited evidence about the clinical or athletic importance of the effect.
-
Acute Citrulline-Malate Supplementation and High-Intensity Cycling Performance.
This citation reports a human clinical study involving Citrulline Malate. It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.
3 published studies referenced in the app, each with a plain-language summary.