Chlorophyll

Plant Pigment

Chlorophyll is a family of magnesium-containing photosynthetic pigments, not one compound. Commercial liquid products may contain chlorophyllin, which is a distinct semisynthetic mixture. Evidence for chlorophyllin must not be represented as evidence for intact natural chlorophyll.

Pharmacokinetic model

A route-level PK model for chlorophyll is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category
Plant Pigment
Suggested cadence
once daily

Research behind this entry

  1. Enhancing Health Benefits through Chlorophylls and Chlorophyll-Rich Agro-Food: A Comprehensive Review Martins T, Barros AN, Rosa E, Antunes L · Molecules, 2023 DOI

    This broad review describes multiple chlorophyll species, derivatives, food matrices, and mostly preclinical findings. Its heterogeneity reinforces that “chlorophyll” is not one doseable parent compound or validated PK…

  2. Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B1 pharmacokinetics in human volunteers Jubert C, Mata J, Bench G, Dashwood R, Pereira C, Tracewell W, Turteltaub K, Williams D, Bailey G · Cancer Prevention Research, 2009 DOI

    An unblinded crossover experiment in four volunteers examined purified chlorophyll a or chlorophyllin coadministered with a tracer dose of aflatoxin B1. Both altered aflatoxin exposure in some participants, but the tiny…

  3. Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer. Egner PA, Wang JB, Zhu YR, Zhang BC, Wu Y, Zhang QN, Qian GS, Kuang SY, Gange SJ, Jacobson LP, Helzlsouer KJ, Bailey GS, Groopman JD, Kensler TW · Proceedings of the National Academy of Sciences of the United States of America, 2001 DOI

    This citation reports a human clinical study involving analogue or class evidence, not direct identity-level evidence for Chlorophyll. The trial administered chlorophyllin, a semisynthetic water-soluble chlorophyll…

3 published studies referenced in the app, each with a plain-language summary.