Centrophenoxine
Centrophenoxine, also called meclofenoxate, is an ester historically investigated in older adults and experimental aging models. The clinical literature is old and limited and does not establish use as a general cognitive enhancer in healthy people.
Pharmacokinetic model
A route-level PK model for centrophenoxine is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Nootropic Drug
- Suggested cadence
- once daily
Research behind this entry
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Modulatory effects of centrophenoxine on different regions of ageing rat brain
Six weeks of intraperitoneal centrophenoxine changed antioxidant markers and lipid peroxidation in aged rats. This preclinical study cannot define oral human cognition, safety, dose, or pharmacokinetics.
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Effects of centrophenoxine on body composition and some biochemical parameters of demented elderly people as revealed in a double-blind clinical trial
Fifty institutionalized older adults with dementia entered an eight-week double-blind trial of 2 g/day or placebo after a placebo run-in. The report described psychometric and intracellular-water changes, but its small,…
2 published studies referenced in the app, each with a plain-language summary.