Home › Compound Library › Casein Protein (Micellar)

Casein Protein (Micellar)

Proteinoral · inferred

Slow-digesting milk protein that forms a gel in the stomach, providing sustained amino acid release over 5-7 hours. Often used before sleep to support overnight muscle protein synthesis.

Projected serum levels — 30 g (≈ 30k mg), once daily

Casein Protein (Micellar)
Casein Protein (Micellar) modeled serum levels, 30 g (≈ 30k mg) once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 5k 10k 15k 20k Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 30 g (≈ 30k mg) once daily (oral).

Modeled steady state after ~1 days: peak ≈ 11.3k mg, trough ≈ 582 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Protein
Route modeled
Oral
Model confidence
inferred
Half-life
4.9 h
Common dose
30 g (≈ 30k mg)
Suggested maximum
75 g/day
Reference dose range
15–75 g (single dose)
Suggested cadence
once daily

Documented interactions

  • caution
    Iron (Bisglycinate) + Casein Protein (Micellar) Absorption

    Casein protein significantly inhibits non-heme iron absorption due to its calcium content and caseinophosphopeptides that bind iron.

  • info
    Calcium (Citrate) + Casein Protein (Micellar) Absorption

    Casein already contains calcium; additional calcium supplements at the same time may reduce iron absorption. Consider spacing if iron status is a concern.

Serum checks 2 modeled interaction pairings for casein protein (micellar) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Protein ingestion before sleep improves postexercise overnight recovery Res PT et al. · Medicine & Science in Sports & Exercise, 2012 DOI

    Ingestion of 40g casein protein before sleep was effectively digested and absorbed during overnight sleep, stimulating muscle protein synthesis and improving whole-body protein balance.

  2. Slow and fast dietary proteins differently modulate postprandial protein accretion Boirie Y et al. · Proceedings of the National Academy of Sciences, 1997 DOI

    Landmark study establishing casein as a "slow" protein that inhibits protein breakdown, while whey is a "fast" protein that stimulates protein synthesis — each with distinct metabolic advantages.

2 published studies referenced in the app, each with a plain-language summary.