Butyrate
Short-Chain Fatty Acid
Butyrate is a short-chain fatty acid produced by colonic microbes and supplied in several non-equivalent supplement forms. Sodium butyrate trial results cannot be assigned to every salt, ester, formulation, or to endogenous butyrate production.
Pharmacokinetic model
A route-level PK model for butyrate is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Short-Chain Fatty Acid
- Suggested cadence
- once daily
Research behind this entry
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Effects of short-chain fatty acid-butyrate supplementation on expression of circadian-clock genes, sleep quality, and inflammation in patients with active ulcerative colitis: a double-blind randomized controlled trial
Thirty-six people with active ulcerative colitis were randomized to a sodium-butyrate preparation or placebo for 12 weeks; several inflammatory, clock-gene, sleep, and quality-of-life measures favored the active arm.…
1 published study referenced in the app, each with a plain-language summary.