Bromelain
Pineapple-derived proteolytic enzyme preparations used in oral and topical products. Reviews combine different doses, activity units, products, indications, and combination therapies, producing inconsistent clinical evidence.
Pharmacokinetic model
A route-level PK model for bromelain is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Supplement
- Suggested cadence
- once daily
Research behind this entry
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Efficacy and safety of bromelain: A systematic review and meta-analysis
Review included 54 articles qualitatively and 39 in meta-analyses across diverse indications, formulations, and comparators. Signals were condition-specific and heterogeneous rather than evidence for one generic…
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Bromelain supplementation and inflammatory markers: A systematic review of clinical trials
Seven randomized trials used bromelain alone or in combinations with widely varying doses, durations, populations, and inflammatory markers. The review judged the overall effect inconsistent; the verified record is PMID…
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Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study.
This citation reports a human clinical study involving Bromelain. It does not by itself establish a qualified dose, safety profile, efficacy claim, or pharmacokinetic route for this record.
3 published studies referenced in the app, each with a plain-language summary.