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Biktarvy (BIC/FTC/TAF)

Antiretroviralprescriptionoral · inferred

Single-tablet HIV regimen containing bictegravir 50 mg, emtricitabine 200 mg, and tenofovir alafenamide 25 mg. One of the most prescribed first-line HIV regimens globally. Dose-limiting PK is bictegravir's plasma half-life (~18h). One pill once daily; well-tolerated with high barrier to resistance.

Projected serum levels — 1 pill (≈ 275 mg), once daily

Biktarvy (BIC/FTC/TAF)
Biktarvy (BIC/FTC/TAF) modeled serum levels, 1 pill (≈ 275 mg) once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 50 100 150 200 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 1 pill (≈ 275 mg) once daily (oral).

Modeled steady state after ~1 days: peak ≈ 104 mg, trough ≈ 5.3 mg body load. Population-based estimate over 15 days for a reference dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Antiretroviral
Route modeled
Oral
Model confidence
inferred
Half-life
4.9 h
Common dose
1 pill (≈ 275 mg)
Suggested maximum
1 pill/day
Reference dose range
0.50–1 pill (single dose)
Suggested cadence
once daily

Documented interactions

  • watch
    Bictegravir (BIC) + Biktarvy (BIC/FTC/TAF) Stacked effects

    Bictegravir (BIC) and Biktarvy (BIC/FTC/TAF) both push the hiv integrase in the same direction.

  • watch
    Cabotegravir (Apretude / Vocabria) + Biktarvy (BIC/FTC/TAF) Stacked effects

    Biktarvy (BIC/FTC/TAF) and Cabotegravir (Apretude / Vocabria) both push the hiv integrase in the same direction.

  • watch
    Descovy (TAF/FTC) + Biktarvy (BIC/FTC/TAF) Stacked effects

    Biktarvy (BIC/FTC/TAF) and Descovy (TAF/FTC) both push the hiv reverse transcriptase nrti in the same direction.

  • watch
    Dolutegravir (DTG / Tivicay) + Biktarvy (BIC/FTC/TAF) Stacked effects

    Biktarvy (BIC/FTC/TAF) and Dolutegravir (DTG / Tivicay) both push the hiv integrase in the same direction.

  • watch
    Emtricitabine (FTC / Emtriva) + Biktarvy (BIC/FTC/TAF) Stacked effects

    Biktarvy (BIC/FTC/TAF) and Emtricitabine (FTC / Emtriva) both push the hiv reverse transcriptase nrti in the same direction.

  • watch
    Lamivudine (3TC, Epivir) + Biktarvy (BIC/FTC/TAF) Stacked effects

    Biktarvy (BIC/FTC/TAF) and Lamivudine (3TC, Epivir) both push the hiv reverse transcriptase nrti in the same direction.

Serum checks 8 modeled interaction pairings for biktarvy (bic/ftc/taf) across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Coformulated bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1 infection Sax PE et al. · Lancet, 2017 DOI

    Phase 3 GS-1489 trial showing Biktarvy non-inferior to DTG/ABC/3TC with favorable tolerability, supporting its adoption as preferred first-line regimen.

  2. Switching to bictegravir/emtricitabine/tenofovir alafenamide in virologically suppressed adults with HIV Daar ES et al. · Lancet HIV, 2018 DOI

    Switch trial confirming maintenance of virologic suppression and improved tolerability after switching to Biktarvy from boosted PI or older INSTI regimens.

2 published studies referenced in the app, each with a plain-language summary.