Betaine HCl
Betaine hydrochloride is an acidifying salt sold for suspected low stomach acid. A small induced-hypochlorhydria pilot showed transient gastric reacidification; evidence for routine symptom treatment and long-term safety remains limited. It is distinct from betaine/TMG.
Pharmacokinetic model
A route-level PK model for betaine hcl is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Digestive Supplement
- Suggested cadence
- once daily
Research behind this entry
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Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria
Six healthy volunteers with rabeprazole-induced hypochlorhydria received 1500 mg. Gastric pH fell rapidly and remained below four for about 77 minutes on average; this small artificial model does not establish clinical…
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Meal-Time Supplementation with Betaine HCl for Functional Hypochlorhydria: What is the Evidence?
Narrative review discusses the rationale and sparse evidence for mealtime betaine HCl. It does not supply controlled evidence for broad symptom claims or a systemic PK model.
2 published studies referenced in the app, each with a plain-language summary.