Beta-Sitosterol

Phytosterol

Beta-sitosterol is a dietary plant sterol with very low oral bioavailability. Free sterol and ester products require separate dose accounting.

Pharmacokinetic model

A route-level PK model for beta-sitosterol is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category
Phytosterol
Suggested cadence
once daily

Research behind this entry

  1. Absolute oral bioavailability and metabolic turnover of beta-sitosterol in healthy subjects Duchateau G, Cochrane B, Windebank S, Herudzinska J, Sanghera D, Burian A, Müller M, Zeitlinger M, Lappin G · Drug Metabolism and Disposition, 2012 DOI

    Oral and intravenous radiolabeled microtracers in healthy adults estimated 0.41% absolute bioavailability, 85 mL/h clearance, and a 46 L distribution volume. The microdose design does not validate supplement-dose…

1 published study referenced in the app, each with a plain-language summary.