Beta-Carotene
Provitamin A carotenoid found in foods and supplements. Supplemental beta-carotene has not prevented cancer or cardiovascular disease in large trial syntheses and can increase lung-cancer risk in people who smoke.
Pharmacokinetic model
A route-level PK model for beta-carotene is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Carotenoid
- Suggested cadence
- once daily
Research behind this entry
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Association between beta-carotene supplementation and risk of cancer: a meta-analysis of randomized controlled trials
Synthesis of 18 reports from eight randomized trials found no reduction in overall cancer incidence and a higher lung-cancer risk with supplementation, especially among participants who smoked. The finding does not…
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Beta-Carotene Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta-analysis of ten trials reported no cardiovascular benefit and a modest increase in cardiovascular mortality with supplementation. Smoking was an important risk context in subgroup analyses.
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A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.
This citation reports a human clinical study involving a formulation related to Beta-Carotene, not the isolated identity. The randomized trial used beta-carotene in a multi-nutrient formulation, so isolated…
3 published studies referenced in the app, each with a plain-language summary.