Bergamot

Supplement

Citrus bergamia products marketed for lipid and metabolic support. Small preparation-specific trials report changes in selected biomarkers, but formulations vary and some evidence comes from combination products.

Pharmacokinetic model

A route-level PK model for bergamot is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category: Supplement
Suggested cadence: once daily

Research behind this entry

A Randomized, Double-Blind, Placebo-Controlled Clinical Trial on the Effect of a Dietary Supplement Containing Dry Artichoke and Bergamot Extracts on Metabolic and Vascular Risk Factors in Individuals with Suboptimal Cholesterol Levels Fogacci F, Giovannini M, Di Micoli A, Fiorini G, Grandi E, Borghi C, Cicero AFG · Nutrients, 2024 DOI
Randomized trial of a supplement combining dry artichoke and bergamot extracts. Any observed effect cannot isolate bergamot or establish equivalence to bergamot-only products.
Bergamot phytosome improved visceral fat and plasma lipid profiles in overweight and obese class I subject with mild hypercholesterolemia: A randomized placebo controlled trial Rondanelli M, Peroni G, Riva A, Petrangolini G, Allegrini P, Fazia T, Bernardinelli L, Naso M, Faliva MA, Tartara A, Gasparri C, Infantino V, Perna S · Phytotherapy Research, 2021 DOI
Placebo-controlled trial of a specific bergamot phytosome formulation in adults with mild hypercholesterolemia. The result is formulation- and population-specific and does not validate a generic extract curve.

2 published studies referenced in the app, each with a plain-language summary.