Artichoke Extract

Herb

Cynara scolymus leaf products studied for lipid and metabolic outcomes. Meta-analyses report modest average changes across heterogeneous trials, while individual extracts and populations vary substantially.

Pharmacokinetic model

A route-level PK model for artichoke extract is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.

Key facts

Category: Herb
Suggested cadence: once daily

Research behind this entry

Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: A systematic review and dose-response meta-analysis of randomized controlled trials Shahinfar H, Bazshahi E, Amini MR, Payandeh N, Pourreza S, Noruzi Z, Shab-Bidar S · Phytotherapy Research, 2021 DOI
Systematic review and dose-response meta-analysis of randomized trials examining lipid outcomes. The pooled estimates combine different juices, extracts, doses, durations, and participant groups.
Antioxidant response to artichoke leaf extract supplementation in metabolic syndrome: A double-blind placebo-controlled randomized clinical trial Rezazadeh K, Aliashrafi S, Asghari-Jafarabadi M, Ebrahimi-Mameghani M · Clinical Nutrition, 2018 DOI
Placebo-controlled trial of a defined artichoke leaf extract in people with metabolic syndrome. Its preparation-specific antioxidant findings do not establish interchangeability with arbitrary commercial extracts.

2 published studies referenced in the app, each with a plain-language summary.