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Amoxicillin

Antibioticprescriptionoral · inferred

Aminopenicillin beta-lactam antibiotic with broad-spectrum activity against gram-positive and many gram-negative bacteria. Inhibits bacterial cell wall synthesis by binding penicillin-binding proteins. Well absorbed orally (~90% bioavailability) regardless of food. Most prescribed antibiotic worldwide. Renally eliminated; dose adjust in renal impairment.

Projected serum levels — 500 mg, once daily

Amoxicillin
Amoxicillin modeled serum levels, 500 mg once daily over 15 days Population-based pharmacokinetic estimate. Steady state reached after approximately 1 days. 0 62.5 125 188 250 Day 0 Day 4 Day 8 Day 11 Day 15 Time on a regular schedule ≈ steady state · day 1

Maintenance schedule: 500 mg once daily (oral).

Modeled steady state after ~1 days: peak ≈ 197 mg, trough ≈ 0.000 mg body load. Population-based estimate over 15 days for a 500 mg dose at a 70 kg reference body mass — the interactive app scales curves to your doses, timing, and body mass.

Key facts

Category
Antibiotic
Route modeled
Oral
Model confidence
inferred
Half-life
1.1 h
Common dose
500 mg
Suggested maximum
3k mg/day
Reference dose range
250–3k mg (single dose)
Suggested cadence
once daily
Validated against
500 mg oral — Cmax 7.5 mg/L at 1.5 h

Documented interactions

  • warning
    Warfarin (Coumadin) + Amoxicillin Potentiation

    Amoxicillin inhibits CYP2C9 and reduces vitamin K-producing gut flora; increases warfarin effect and INR.

  • caution
    Ethinyl Estradiol + Amoxicillin Depletion

    Broad-spectrum antibiotics may reduce enterohepatic recirculation of ethinyl estradiol by disrupting gut bacteria responsible for deconjugating EE glucuronides. This can transiently lower EE levels…

Serum checks 2 modeled interaction pairings for amoxicillin across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.

Research behind this entry

  1. Pharmacokinetics of amoxicillin: dose dependence after intravenous, oral, and intramuscular administration Spyker DA et al. · Antimicrobial Agents and Chemotherapy, 1977 DOI

    Definitive PK study establishing amoxicillin half-life of 1-1.5 hours, 90% oral bioavailability, dose-proportional pharmacokinetics, and predominantly renal elimination with 60-70% unchanged in urine.

  2. Amoxicillin: a review of its use in the management of otitis media and other common infections Todd PA, Benfield P · Drugs, 1990 DOI

    Comprehensive review establishing amoxicillin as first-line therapy for otitis media, sinusitis, UTIs, and lower respiratory infections with excellent oral absorption and tolerability.

2 published studies referenced in the app, each with a plain-language summary.