Alpha-Ketoglutarate (AKG)
Alpha-ketoglutarate is an endogenous tricarboxylic-acid-cycle intermediate. Free AKG, calcium AKG, ornithine AKG, and mixed keto-acid products are distinct interventions. Longevity claims rely heavily on preclinical or uncontrolled evidence.
Pharmacokinetic model
A route-level PK model for alpha-ketoglutarate (akg) is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Endogenous Metabolite
- Suggested cadence
- once daily
Research behind this entry
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Improved training tolerance by supplementation with alpha-Keto acids in untrained young adults: a randomized, double blind, placebo-controlled trial
Thirty-three untrained men received AKG, branched-chain keto acids, or placebo during four weeks of intensive training. Only nine were assigned to AKG, and several training measures differed; the small short trial does…
1 published study referenced in the app, each with a plain-language summary.