6-Mercaptopurine
Antimetaboliteprescription
Active metabolite of azathioprine; itself a directly-dosed chemotherapy (Purinethol). TPMT-activated to 6-TGN.
Pharmacokinetic model
A route-level PK model for 6-mercaptopurine is being prepared from published data. Dosing references, studies, and documented interactions are below; the app catalog is updated as models are validated.
Key facts
- Category
- Antimetabolite
- Half-life
- 1.5 h
- Reference dose range
- 1–8 mg (single dose)
- Suggested cadence
- custom (shown daily)
- Validated against
- 75 mg oral — Cmax 0.085 mg/L at 2 h
Documented interactions
-
moderate
Azathioprine (Imuran) + 6-Mercaptopurine
6-Mercaptopurine and Azathioprine (Imuran) both push the dna purine incorporation and tpmt in the same direction.
Serum checks 1 modeled interaction pairings for 6-mercaptopurine across your whole stack — absorption conflicts, enzyme inhibition, and nutrient depletion included.